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Utility of Cryopreserved Hepatocytes Suspended in Serum to Predict Hepatic Clearance in Dogs and Monkeys
Drug Metabolism and Pharmacokinetics
An in vitroin vivo correlation analysis between observed and predicted metabolic clearance in multiple preclinical species including dogs and monkeys constitutes an integral part of prediction for the pharmacokinetics in humans by using liver-derived in vitro preparations. Empirical values of the scaling factor for the extrapolation of metabolic (intrinsic) clearance in the in vitro preparation to that for whole liver were calculated for each preparation of 8 and 5 cryopreserved dog and monkeydoi:10.2133/dmpk.dmpk-13-rg-083 pmid:24042473 fatcat:iazuvq47lja2pkjjwfpe2cc7ha