Chemogenetic Tools for Causal Cellular and Neuronal Biology

Deniz Atasoy, Scott M. Sternson
2018 Physiological Reviews  
Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological control over G protein-coupled receptor signaling, ion channel conductances, protein association, protein stability, and small molecule targeting allows modulation of cellular processes in distinct cell types. Here, we review these chemogenetic technologies and instances of
more » ... and instances of their applications in complex tissues in vivo and ex vivo.
doi:10.1152/physrev.00009.2017 pmid:29351511 fatcat:o5rlcbri2ba77izk7ipi4i7b5e