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Investigating Interactions Among Genetic and Environmental Risk Factors in Longitudinal Family Studies with Application to the Quebec Newborn Twin Study
2017
Gene-environment (GE) interactions involving the IGF pathway may affect childhood obesity. Detecting such interactions using longitudinal family studies requires accounting for individual and familial correlations. Simulations were performed to study three methods to test for GE interactions in longitudinal family data using repeated outcomes (linear mixed model) or individual outcome averages as summary statistics (twin model, partition based score I test). Interactions between the IGF pathway
doi:10.20381/ruor-20818
fatcat:m3ff7q3i7jha7fpfml7ajjjicy