Synthesis of stable cannabidiol (CBD) nanoparticles in suspension
Sinteza stabilnih nanodelcev kanabidiola (CBD) v suspenzijah

R. Štukelj, M. Benčina, M. Fanetti, M. Valant, M. Drab, A. Iglič, V. Kralj-Iglič
2019 Materiali in Tehnologije  
The reduction of cannabidiol (CBD) particle size in suspensions and maintenance of their stability is crucial for improved bioavailability and an increase in CBD's therapeutic effects. Here we report on a facile and cost-effective precipitation method for fast CBD nanonization. The characterization of the particle size in various suspensions was determined by dynamic light scattering (DLS), while scanning electron microscopy (SEM) analysis was performed to obtain the size and morphology of the
more » ... ried CBD particles. The influence of the synthesis parameters (type and concentration of solvents and surfactants) on the size of the CBD particles in suspension were evaluated. By addition of the surfactants, the agglomeration of CBD nanoparticles (NPs) in suspension was prevented and the suspensions maintained stability for up to 9 months. Zmanj{anje velikosti delcev kanabidiola (CBD) v suspenzijah in vzdr'evanje njihove stabilnosti je klju~nega pomena za izbolj{anje biolo{ke uporabnosti in pove~anje terapevtskega u~inka CBD. Predstavljena je sinteza nanodelcev kanabidiola v suspenziji z reakcijo obarjanja. Velikost delcev CBD v razli~nih suspenzijah smo izmerili z metodo dinami~nega sipanja svetlobe (DLS), medtem ko smo velikost in obliko posu{enih nanodelcev CBD analizirali z vrsti~no elektronko mikroskopijo (SEM). Preu~ili smo vpliv sinteznih parametrov (vrsta in koncentracija topila, dodatek surfaktantov) na morfologijo CBD delcev. Z dodatkom surfaktantov smo prepre~ili aglomeracijo nanodelcev CBD ter supenzije ohranili stabilne do 9 mesecev.
doi:10.17222/mit.2018.253 fatcat:fua7dgahajga5huy7f54tes5em