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Apart from its known function, the plasma membrane Ca2+ATPase can regulate Ca2+ signaling by controlling phosphatidylinositol 4,5-bisphosphate levels
2013
Journal of Cell Science
Plasma membrane Ca 2+ ATPases (PMCAs, also known as ATP2B1-ATP2B4) are known targets of phosphatidylinositol 4,5bisphosphate [PtdIns(4,5)P 2 ], but if and how they control the PtdIns(4,5)P 2 pool has not been considered. We demonstrate here that PMCAs protect PtdIns(4,5)P 2 in the plasma membrane from hydrolysis by phospholipase C (PLC). Comparison of active and inactive PMCAs indicates that the protection operates by two mechanisms; one requiring active PMCAs, the other not. It appears that
doi:10.1242/jcs.132548
pmid:24198396
fatcat:sbtff6ayvjah7gxroezdbfua74