A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
Cardioprotection by the TSPO ligand 4′-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion
2013
Cardiovascular Research
Aims: The translocator protein(TSPO) is located on the outer mitochondrial membrane where it is responsible for the uptake of cholesterol into mitochondria of steroidogenic organs. TSPO is also present in the heart where its role remains uncertain. We recently showed that TSPO ligands reduced infarct size and improved mitochondrial functions after ischemiareperfusion. This study thus sought to determine whether cholesterol could play a role in the cardioprotective effect of TSPO ligands.
doi:10.1093/cvr/cvt079
pmid:23554458
fatcat:s3hbno37ebfpnebi66twmyp47u