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Role of Macrocyclic Conformational Steering in a Kinetic Route toward Bielschowskysin
[post]
2020
unpublished
Macrocyclic furanobutenolide-derived cembranoids (FBCs) are the biosynthetic precursors to a wide variety of highly congested and oxygenated polycyclic (nor)diterpenes (<i>e.g.</i> plumarellide, verrillin or bielschowskysin). These architecturally complex metabolites are thought to originate from site-selective oxidation of the macrocycles' backbone and a series of intricate transannular reactions. Yet the development of a common biomimetic route has been hampered by a lack of synthetic methods
doi:10.26434/chemrxiv.13377173.v1
fatcat:4g5ea2t6cvhetorov6b2qr6i44