PRACE ORYGINALNE/ORIGINAL PAPERS

Mariusz Nowak, Mariusz Nowak, Tomasz Wielkoszyński, Beata Kos-Kudła, Bogdan Marek, Jacek Karpe, Dariusz Kajdaniuk, Lucyna Siemińska, Joanna Głogowska-Szeląg, Wanda Foltyn, Janusz Strzelczyk, Katarzyna Nowak
unpublished
The blood concentration of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in patients with active thyroid-associated orbitopathy before and after methylprednisolone treatment Stężenie międzykomórkowej cząstki adhezyjnej-1 (sICAM-1) oraz naczyniowej cząstki adhezyjnej-1 (sVCAM-1) w surowicy krwi chorych z aktywną formą orbitopatii tarczycowej przed oraz po leczeniu metylprednizolonem Abstract Background: The soluble forms of vascular cell adhesion
more » ... cule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) have been found to be increased in the blood of patients with Graves' disease. The aim of this study is evaluation of the serum concentrations of soluble forms of adhesion molecules ICAM-1 and VCAM-1 in patients with thyroid-associated orbitopathy (TAO) before and after methylprednisolone treatment. Material and methods: The study was performed in 40 Graves'disease, hyperthyroid and euthyroid patients with a clinically active form of TAO. Serum concentrations of sVCAM-1 and sICAM-1 in TAO patients were determined by enzyme-linked immunoabsorbent assay (ELISA) before and after intensive pulse methylprednisolone treatment. Results: We did not find any significant changes in the studied parameters between TAO patients with hyperthyroidism and those with euthyroidism. The serum concentrations of sICAM-1 and sVCAM-1 were significantly increased in patients with TAO before methylprednisolone therapy when compared with the control group. After treatment serum concentrations of sICAM-1 and sVCAM-1 decreased significantly but were still significantly higher than for the control group. Conclusion: From the results obtained we can conclude that Graves' orbitopathy itself but not thyroid function is probably responsible for the elevated level of the adhesion molecules studied.
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