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Functional Role and Prognostic Significance of CD157 in Ovarian Carcinoma
Journal of the National Cancer Institute
Results CD157 was expressed by ovarian cancer cells and mesothelium, and it potentiated the adhesion, migration, and invasion of serous ovarian cancer cells through different extracellular matrices. CD157-transfected ovarian cancer cells migrated twice as much as CD157-negative control cells (P = .001). Blockage of CD157 inhibited mesothelial invasion by serous ovarian cancer cells in a three-dimensional model. CD157 was expressed in 82 (93%) of the 88 epithelial ovarian cancer tissuedoi:10.1093/jnci/djq256 pmid:20639476 fatcat:4ul2smfu4nfxhnhjnmqspzm5ay