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A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5–5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system
The Escherichia coli mu operon was subcloned into a pKK233-2 vector containing rat glutathione S-transferase (GST) 5-5 cDNA and the plasmid thus obtained was introduced into Salmonella typhimurium TA1535. The newly developed strain S.typhimurium NM5004, was found to have 52-fold greater GST activity than the original umu strain S.typhimurium TA1535/pSK1002. We compared sensitivities of these two tester strains, NM5004 and TA1535/ pSK1002, for induction of umuC gene expression with severaldoi:10.1093/carcin/17.2.297 pmid:8625454 fatcat:xnzbf3ixpbdgzdwa5zry2jrp6y