Different topological organization of human brain functional networks with eyes open versus eyes closed

Pengfei Xu, Ruiwang Huang, Jinhui Wang, Nicholas T. Van Dam, Teng Xie, Zhangye Dong, Chunping Chen, Ruolei Gu, Yu-Feng Zang, Yong He, Jin Fan, Yue-jia Luo
2014 NeuroImage  
Resting-state functional MRI 30 Opening and closing the eyes are a fundamental behavior for directing attention to the external versus internal 31 world. However, it remains unclear whether the states of eyes-open (EO) relative to eyes-closed (EC) are associ-32 ated with different topological organizations of functional neural networks for exteroceptive and interoceptive 33 processing (processing the external world and internal state, respectively). Here, we used resting-state functional 34
more » ... e functional 34 magnetic resonance imaging and neural network analysis to investigate the topological properties of functional 35 networks of the human brain when the eyes were open versus closed. The brain networks exhibited increased 36 cliquishness and increased local efficiency, but lower global efficiency during the EO state. Together, these prop-37 erties suggest an increase in specialized information processing along with a decrease in integrated information 38 processing in EO (vs. EC). More importantly, the "exteroceptive" network, including the attentional system (e.g., 39 superior parietal gyrus and inferior parietal lobule), ocular motor system (e.g., precentral gyrus and superior 40 frontal gyrus), and arousal system (e.g., insula and thalamus), showed higher regional nodal properties (nodal 41 degree, efficiency and betweenness centrality) in EO relative to EC. In contrast, the "interoceptive" network, com-42 posed of visual system (e.g., lingual gyrus, fusiform gyrus and cuneus), auditory system (e.g., Heschl's gyurs), so-43 matosensory system (e.g., postcentral gyrus), and part of the default mode network (e.g., angular gyrus and 44 anterior cingulate gyrus), showed significantly higher regional properties in EC vs. EO. In addition, the connec-45 tions across sensory modalities were altered by volitional eye opening. The synchronicity among visual system 46 and motor, somatosensory and auditory system characteristics of EC was attenuated in EO, and the connections 47 among visual system and attention, arousal and subcortical systems were increased in EO. These results may in-48 dicate that EO leads to a suppression of sensory modalities (other than visual) to allocate resources to exterocep-49 tive processing. Our findings suggest that the topological organization of human brain networks dynamically 50 switches corresponding to the information processing modes as we open or close our eyes. 51
doi:10.1016/j.neuroimage.2013.12.060 pmid:24434242 fatcat:2melyq23nfcz3icz3efq4xv54q