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The living cell is an incredibly complex entity, and the goal of predictively and quantitatively understanding its function is one of the next great challenges in biology. Much of what we know about the cell concerns its constituent parts, but to a great extent we have yet to decode how these parts are organized to yield complex physiological function. Classically, we have learned about the organization of cellular networks by disrupting them through genetic or chemical means. The emergingdoi:10.1146/annurev.biophys.050708.133652 pmid:20192780 pmcid:PMC2965450 fatcat:je4bki77pfbtvadcq73lhxh3li