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Artefactual gene induction during preparation of Xenopus laevis animal cap explants
International Journal of Developmental Biology
The animal cap assay in Xenopus laevis was used to study the induction and regulation of the mesoderm-specific gene Xegr-1, a homolog of the mammalian egr-1 genes. Egr-1 is an immediate-early gene whose growth factor-stimulated transcriptional induction displays a transient activity profile and occurs independent of protein synthesis. The Xegr-1 promoter contains multiple serum response elements (SREs). In this paper we show that Xegr-1 is induced unspecifically during the process of animal cappmid:10610029 fatcat:gqddkfty45hurjrhmz5msmk3jm