Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study

Sandra Waaijenborg, Aeilko H Zwinderman
2009 BMC Proceedings  
Cardiovascular diseases are associated with combinations of phenotypic traits, which are in turn caused by a combination of environmental and genetic factors. Because of the diversity of pathways that may lead to cardiovascular diseases, we examined the so-called intermediate phenotypes, which are often repeatedly measured. We developed a penalized nonlinear canonical correlation analysis to associate multiple repeatedly measured traits with high-dimensional single-nucleotide polymorphism data.
doi:10.1186/1753-6561-3-s7-s47 pmid:20018039 pmcid:PMC2795946 fatcat:7kajl6n7rnbv5khuc5jrbipg4m