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MOLECULAR DOCKING AND ANALYSIS OF LAWSONE DERIVATIVES AS POTENT INHIBITORS IN MUTANT BRCA 1 PROTEIN IN BREAST CANCER
2021
International Journal of Biology Pharmacy and Allied Sciences
Breast cancer is one of the dangerous types of cancer that affect women. BRCA1 and BRCA2 genes are responsible for the tumor progression in breast cancer patients. In the current work, we are focusing on in silico molecular docking analysis of hydroxynaphthoquinone (Lawsone) derivatives. The docking results were compared with the standard drug, Olaparib which is currently used in BRCA1 mutated breast cancers. From the docking studies, using Discovery studio 2018 software, it was found that the
doi:10.31032/ijbpas/2021/10.10.5525
fatcat:nwb3w4u7zvgzznxuq4yodu3l7e