Case Report An Unusually Large Granular Cell Tumor of the Pharynx: A Case Report and Literature Review

Xiaoxian Li, Robert Parke, Jennifer Rushton, Anna Sienko1, Qihui, Jim Zhai
2009 Int J Clin Exp Pathol   unpublished
We report a granular cell tumor of the pharynx in a 53 year-old woman who presented with a large retropharyngeal mass. Surgical excision revealed a 5.5 cm tan rubbery unencapsulated but circumscribed mass. Histologically, the tumor is composed of diffusely arranged oval and spindle cells with abundant eosinophilic granular cytoplasm and mildly pleomorphic nuclei without necrosis or mitoses. Immunostains show the tumor cells to be positive for S-100, vimentin, non-specific esterase and focally
more » ... erase and focally positive for inhibin. In addition to its unusual location, this tumor is extremely large while most granular cell tumors are small (<2 cm). This case represents a unique example of a large granular cell tumor at a rare location: the pharynx.