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Deep phenotyping study has become an emerging field to understand the gene function and the structure of biological networks. For the living animal C. elegans, recent advances in genome-editing tools, microfluidic devices and phenotypic analyses allow for a deeper understanding of the genotype-to-phenotype pathway. In this article, I reviewed the evolution of deep phenotyping study in cell development, neuron activity, and the behaviors of intact animals.arXiv:1905.02335v1 fatcat:mzmfjpcsifa2bhb2izbqflwrge