The present report was conducted to study the antibacterial activity of the containing fluoride sealants on Streptococcus mutans NCTC 10449, Streptococcus sanguis ATCC 10557 and Lactobacillus casei ATCC 7469. We examined four samples used for the light cured fissure sealants: two sealants containing fluoride(B and C), a sealant with no-fluoride in its (A) and a glassionomer cement (D). We investigated the productivities of the inhibition zone on the agar plates and the effect of viable cell

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... ts in the broth. In addition we measured the concentration of the fluoride ion and the pH from the samples. The results were as follows; 1. The sample A, B and C showed antibacterial activity only toward S. mutans in the aerobic condition. 2. The sample D showed antibacterial activity toward all of the strains tested. 3. The sample D showed the highest fluoride release. 4. The sample D showed the highest pH. In conclution with the use of the fissure sealants, it is possible to inhibit the growth of S. mutans. The property of these materials might have the advantage of the clinical effectiveness of fissure sealants.