Flavouring Group Evaluation 86, (FGE.86) - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food

2008 EFSA Journal  
The present consideration concerns 35 aliphatic and aromatic amines and amides evaluated by the JECFA (65 th meeting). The Panel concluded that no corresponding FGE is available. Further two substances were evaluated by the JECFA in this group, but these are not in the Register (1-amino-2-propanol and acetamide; JECFA-no: 1591 and 1592, respectively). The Panel agreed with the application of the Procedure as performed by the JECFA for 28 of the 35 substances. The JECFA concluded the five
more » ... ded the five substances 14.003, 16.091, 1 For citation purposes: Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from Commission on Flavouring Group Evaluation 86, (FGE.86) Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65 th meeting) The EFSA Journal (2008) 745, 1-45 Flavouring Group Evaluation 86, (FGE.86) Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65 th meeting) The EFSA Journal (2008) 745, 2-46 Flavouring Group Evaluation 86, (FGE.86) Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65 th meeting) The EFSA Journal (2008) 745, 3-46 are needed, and for three substance [FL-no: 11.017, 14.168 and 16.094] identity tests are missing. Thus, for seven substances 11.017, 14.064, 14.168, 16.013, 16.053 and 16.094] the Panel has reservations (no European production volumes available, preventing them from being evaluated using the Procedure, and/or missing data on specifications and/or information on stereoisomerism /composition). For seven of the 35 evaluated substances the Panel did not agree with the JECFA application of the Procedure and additional toxicity data are required for five of the seven substances [FLno: 11.014, 14.003, 16.091, 16.093 and 16.094]. One substance cannot be evaluated through the Procedure due to concern with respect to genotoxicity/carcinogenicity .049] and one substance .017] is evaluated along the A-side, while the JECFA evaluated it along the B-side. Overall, for the remaining 23 of the 35 JECFA evaluated aliphatic and aromatic amines and amides [.052 and 16.092] the Panel agreed with the JECFA conclusion "no safety concern at estimated levels of intake as flavouring substances" based on the MSDI approach.
doi:10.2903/j.efsa.2008.745 fatcat:6d6x7brssbdfpl5r4u7hr6kxvi