Morphometric analysis of the thymus of puppies infected with the Snyder Hill Strain of canine distemper virus

C.M. Alves, A.C. Vasconcelos, A.S. Martins, H.L. del Puerto, F.G.A. Santos, J.E.S. Nunes, P.P. Campos, L. Moro
2006 Arquivo Brasileiro de Medicina Veterinária e Zootecnia  
The thymic morphometry analysis was used for determining apoptosis and atrophy of the thymus of eight puppies inoculated with canine distemper virus (CDV). Three healthy dogs were used as negative controls. Sections, 5µm thick, were stained by HE and Shorr, and the latter were evaluated by morphometry. CDV nucleoprotein was detected by immunohistochemistry. Morphometric results confirmed lymphoid hypotrophy in CDV inoculated dog thymuses, more stroma, less parenchyma and higher apoptotic
more » ... ield than negative control (not inoculated) puppies. Apoptosis plays a role in the mechanism of thymus atrophy that develops in canine distemper.
doi:10.1590/s0102-09352006000400004 fatcat:rrgsfiobbnghzmzwfqzts5qlpe