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An Inositol 1,4,5-Triphosphate (IP3)-IP3Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes
2010
Endocrinology
Preserved Fulltext
Intracellular calcium levels ([Ca 2ϩ ] i ) and glucose uptake are central to cardiomyocyte physiology, yet connections between them have not been studied. We investigated whether insulin regulates [Ca 2ϩ ] i in cultured cardiomyocytes, the participating mechanisms, and their influence on glucose uptake via SLC2 family of facilitative glucose transporter 4 (GLUT4).
doi:10.1210/en.2010-0116
pmid:20685879
fatcat:57yf6xwt4vfzxeiourfistmsvi