Development of a series of bis-triazoles as G-quadruplex ligands

Maysaa M. Saleh, Charles A. Laughton, Tracey D. Bradshaw, Christopher J. Moody
2017 RSC Advances  
Maintenance of telomeres – specialized complexes that protect the ends of chromosomes – is provided by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells, but absent in most normal cells.
doi:10.1039/c7ra07257k fatcat:qwezci72lrct3occ5g5s4ddyn4