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Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination
Neural stem cells are maintained in the adult brain, sustaining structural and functional plasticity and to some extent participating in brain repair. A thorough understanding of the mechanisms and factors involved in endogenous stem/progenitor cell mobilization is a major challenge in the promotion of spontaneous brain repair. The main neural stem cell niche in the adult brain is the subventricular zone (SVZ). Following demyelination insults, SVZ-derived progenitors act in concert withdoi:10.1242/dev.092999 pmid:23824572 fatcat:p2ai6g44xjh4pijkwpbjbymeuy