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Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation
Graphical Abstract Highlights d DNA damage is sufficient to trigger a global alternative splicing (AS) response to UV d Photolyase-mediated elimination of the DNA lesions (CPDs) abolishes the AS response d RNAPII is the target, but not a sensor, of the signaling cascade initiated by CPDs d GG-NER and ATR participate in the control of RNAPII phosphorylation and AS by UV In Brief Muñ oz et al. find that UV-induced DNA damage is the main determinant affecting gene expression in response to UV indoi:10.1016/j.celrep.2017.02.066 pmid:28329680 fatcat:h4gcrtdzybbj3jdcbothy62mtq