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The Inhibitory Signaling Receptor Protocadherin-18 Regulates Tumor-Infiltrating CD8 + T-cell Function
Cancer immunology research
Cancers are infiltrated with antitumor CD8 þ T cells that arise during tumor growth, but are defective in effector phase functions because of the suppressive microenvironment. The reactivation of TILs can result in tumor destruction, showing that lytic dysfunction in CD8 þ tumor-infiltrating lymphocytes (TIL) permits tumor growth. Like all memory T cells, TILs express inhibitory signaling receptors (aka checkpoint inhibitor molecules) that downregulate TCR-mediated signal transduction upon TILdoi:10.1158/2326-6066.cir-17-0187 pmid:28874354 fatcat:kgzhvw6dore4zbydb4kfpq3nxy