Spondin 1 (SPON1) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes [post]

Shahan Mamoor
2020 unpublished
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that spondin 1, encoded by SPON1, was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes
more » ... to the lymph nodes when compared to primary tumors of the breast or normal breast tissue, respectively. We observed significant down-regulation of SPON1 in metastasis to the brain. Molecular functions and down-regulation of spondin 1 may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer and suggests some level of common origin for metastases that reside in the lymph nodes and colonize the brain.
doi:10.31219/osf.io/gydx4 fatcat:tik2tlelmjaqlca6qx6edcyz4u