Polymorphism and signalling of melatonin receptors

Lena Brydon, Laurence Petit, Pierre de Coppet, Perry Barrett, Peter J. Morgan, A. Donny Strosberg, Ralf Jockers
1999 Reproduction nutrition development (Print)  
Melatonin receptors belong to the superfamily of G protein-coupled receptors. Cloning of Mellc receptors expressed in Xenopus skin revealed the existence of a polymorphism for these receptors. Heterologous expression of the two allelic isoforms, called Mellc(a) and Mellc([3), indicated functional differences in their signalling properties. Both isoforms are coupled to the cAMP and cGMP pathways. However, the a isoform is preferentially coupled to the cAMP pathway, whereas the [3 isoform couples
more » ... [3 isoform couples preferentially to the cGMP pathway. Coupling differences may be explained
doi:10.1051/rnd:19990304 fatcat:kzftxyh4mrbbfbcp34pscywyda