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Melatonin receptors belong to the superfamily of G protein-coupled receptors. Cloning of Mellc receptors expressed in Xenopus skin revealed the existence of a polymorphism for these receptors. Heterologous expression of the two allelic isoforms, called Mellc(a) and Mellc([3), indicated functional differences in their signalling properties. Both isoforms are coupled to the cAMP and cGMP pathways. However, the a isoform is preferentially coupled to the cAMP pathway, whereas the [3 isoform couplesdoi:10.1051/rnd:19990304 fatcat:kzftxyh4mrbbfbcp34pscywyda