Preterm premature rupture of membranes is one of the most common issues in daily obstetrics practice. PPROM is associated with 30% of neonatal morbidities and mortalities in preterm delivery. Increased PLT consumption causes activation and increased production of PLT, which causes a hypercoagulable state and microcirculatory defects and vascular reactivity in the placental bed, resulting in placental insufficiency and adverse neonatal outcomes. The present study aimed to determine platelet

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... es in PPROM patients and to evaluate the association between PLT indices and adverse neonatal outcomes. Material and methods: This was a hospital based descriptive study. 130 women with PROM & 130 women without PROM with gestational age between 24 -36.6 weeks admitted in the labour room for delivery were included in the study. CBC was done for all. Relationship between PLT indices and neonatal outcomes in PPROM cases were analyzed. Results: The mean platelet count in women of study group (224.2 ± 66.43 x10 3 /mm 3 ) was lower than mean platelet count in women of control group (232 ± 71.58 x10 3 /mm 3 ). Mean MPV and PDW were significantly more in study group. There was a weak positive correlation existed between Platelet count and APGAR score and birth weight of the baby. A negative correlation existed between MPV and APGAR and birth weight. Conclusion: Platelet count, MPV and PDW which are simple, economical and rapid to measure, can be used to predict adverse outcome in PPROM.