Valvular lesions in patients with systemic lupus erythematosus and antiphospholipid syndrome: An old disease but a persistent challenge

Ester Ferreira, Paulo M. Bettencourt, Luís M. Moura
2012 Revista Portuguesa de Cardiologia (English Edition)  
Valvular heart disease is common in systemic lupus erythematosus (SLE) and antiphospholipid syndrome. Immunologic insult plays a fundamental role in its pathogenesis but data on the role of antiphospholipid antibodies have been inconsistent, particularly regarding SLE-associated valvular lesions. Although timely diagnosis is essential to prevent progression of valvular lesions, treatment remains a challenge because of the lack of large systematic studies. This article reviews and summarizes
more » ... nt information relating to valvular damage in these two autoimmune diseases, and highlights some important questions that need to be answered.
doi:10.1016/j.repce.2012.04.003 fatcat:6jl6wnpbajfqbmdr6r5lkaue6e