The effects of acute cold exposure and feeding on volatile fatty acid metabolism in the hind leg of the young ox

A. W. Bell, J. W. Gardner, G. E. Thompson
1974 British Journal of Nutrition  
I . Young steers were fed either 20 or 4 h before exposure to a thermoneutral or a moderately cold environment. Measurements were made of total oxygen consumption (total Voz), respiratory quotient (RQ) and hind-leg blood flow (leg Q) and oxygen uptake (leg Voz). The arteriovenous difference in plasma concentrations of individual volatile fatty acids (VFA) across the leg was also measured. Net exchange and fractional uptake of VFA by the leg were calculated from these results. 2. Cold exposure
more » ... ubled ,total po2, significantly decreased the RQ and caused 3-fold and 10-fold increases in leg Q and leg Voz respectively in both 4 h-and 20 h-fed steers. Arterial plasma concentrations of total VFA (which was more than 95 yo acetate) and net leg uptake of VFA also significantly increased in both groups. Cold had no effect on the fractional uptake of VFA by the leg. 3. Feeding shortly before the experiment caused a significant increase in total poz in thermoneutrality only, and in RQ, arterial plasma VFA and net VFA uptake by the leg in both environments. There was a significant decrease in the fractional uptake of VFA by the leg. 4. Calculations suggest that although circuiating acetate could, in theory, supply over 60 yo of the energy required by the hind leg in the resting, fed animal, less than 30 % of the increased requirement of the shivering leg could be supplied by acetate during acute cold exposure, even shortly after feeding.
doi:10.1079/bjn19740098 pmid:4419578 fatcat:uazcxwxjsrhfzksee6vavgjlai