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After heating at 37 ° in minimal Eagle's medium, the alternating polyriboadenylicpolyribouridylic acid [poly r(A-U)] became much more active in producing cellular resistance to virus infection and interferon production in four different cell lines (human skin fibroblasts, mouse embryo fibroblasts, mouse L 929 cells and rabbit kidney (RK 13) cells). The thermal activating effect was neutralized by pre-treatment of the cells with DEAE-dextran, which increased the antiviral activity of unheateddoi:10.1099/0022-1317-10-2-125 pmid:4324254 fatcat:h2rasxlgjjhsvpm3meh4edmq5y