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VEGF blockade decelerates the growth of a murine experimental osteosarcoma
International Journal of Oncology
Retrovirus-mediated sFlt-1 gene modification was performed to examine the influence of VEGF in controlling the growth of an experimental osteosarcoma in mice. Human osteosarcoma G-292 cells were in vitro infected with retroviral vectors encoding soluble Flt-1 or LacZ gene before transplanted into proximal tibiae of immune deficient SCID mice to establish experimental orthotopic osteosarcoma. Daily observation and biweekly microCT were performed to monitor tumor development and progression tilldoi:10.3892/ijo_00000004 fatcat:jfm3w2fnnvhnnjfszoi4in4agy