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The retinoblastoma protein (pRB) is an important regulator of development, proliferation, and cellular differentiation. pRB was recently shown to play a pivotal role in adipocyte differentiation, to interact physically with adipogenic CCAAT/enhancer-binding proteins (C/ EBPs), and to positively regulate transactivation by C/EBP␤. We show that PPAR␥-mediated transactivation is pRB-independent, and that ligand-induced transactivation by PPAR␥1 present in RB ؉/؉ and RB ؊/؊ mouse embryo fibroblastsdoi:10.1074/jbc.274.4.2386 pmid:9891007 fatcat:fovqki4wqrf73frwh5k5beqiwm