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Expression of Hepatocyte Growth Factor-Like Protein Is Repressed by Retinoic Acid and Enhanced by Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein (CREB)-Binding Protein (CBP)
In an effort to understand the molecular mechanisms involved in the regulation of expression of the gene encoding hepatocyte growth factor-like protein (HGFL), it was found that all-trans-retinoic acid dramatically represses expression of the endogenous HGFL gene in HepG2 cells, a human hepatocyte-derived cell line. This repression requires the sequence between nucleotides Ϫ135 and Ϫ105 in the 5Ј-flanking sequence of the HGFL gene, a site that has previously been shown to bind the transcriptiondoi:10.1210/en.140.1.187 pmid:9886825 fatcat:426itubtp5fpbgip37hqsnfwem