Metzincins, including matrix metalloproteinases and meprin, in kidney transplantation

Céline Berthier, Hans-Peter Marti
2007 Swiss Medical Weekly  
Chronic allograft nephropathy, including chronic rejection, remains one of the major causes of renal allograft failure. Amongst other mediators, metzincins, such as matrix metalloproteinases (MMP), direct extracellular matrix metabolism and cell proliferation. Thus, we hypothesized, that these proteolytic enzymes are differentially regulated in chronic renal transplant rejection in rats and in human renal allograft nephropathy. Our studies demonstrated on the experimental level and in humans an
more » ... overall up-regulation of MMP, tissue inhibitors ofmetalloproteinases (TIMP) and related enzymes as a result of rejection processes. Thus, metzincins may represent novel markers and therapeutic targets with respect to renal allograft rejection.
pmid:17874514 fatcat:kjs4elsilnh3ro4a656eh4p2xu