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Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral Use
2016
Acta Chimica Slovenica
Nimesulide belongs to the group of semi-selective COX-2 inhibitors, widely used in solid oral formulations. In the present work, we studied the influence of surfactants among other drug excipients, as well as particle size of the active substance and the effects of medium pH on the dissolution profile of nimesulide from solid pharmaceutical forms. For that purpose, four different preparations containing 100 mg nimesulide per tablet and available on the market of Bosnia and Herzegovina (labeled
doi:10.17344/acsi.2015.2168
fatcat:ivnatsw375e6bh2znvspvv6rme