The extract of Eupenicillium javanicum IFM showed the antifungal activity against Aspergillus fumigatus. The active principle from E. javanicum IFM was determined to be -( -carboxyethyl)--decylmaleic anhydride ( ), by chemical and spectroscopic method. The methyl ester ( ) of was identifi ed with the semi-synthetic one derived from spiculisporic acid. Semi-synthetically prepared inhibited the growth of A. fumigatus, while other related compounds showed only marginal or no activity. To our

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... dge, compound ( ) is the fi rst example of identifi cation from natural sources.