An antifungal substance isolated from Eupenicillium javanicum IFM 58214

Shou NAKADATE, Koohei NOZAWA, Takashi YAGUCHI
2011 JSM Mycotoxins  
The extract of Eupenicillium javanicum IFM showed the antifungal activity against Aspergillus fumigatus. The active principle from E. javanicum IFM was determined to be -( -carboxyethyl)--decylmaleic anhydride ( ), by chemical and spectroscopic method. The methyl ester ( ) of was identifi ed with the semi-synthetic one derived from spiculisporic acid. Semi-synthetically prepared inhibited the growth of A. fumigatus, while other related compounds showed only marginal or no activity. To our
more » ... dge, compound ( ) is the fi rst example of identifi cation from natural sources.
doi:10.2520/myco.61.41 fatcat:nzwiridpfnhl3g23ypy4cmbqxe