Optimizing Pharmacokinetic/Pharmacodynamics Principles & Role of Cefoperazone-Sulbactam

M Singh, Kochhar
2010 Pharmacologyonline   unpublished
Antimicrobial resistance is associated with adverse patient outcomes and increased resource utilization. With limited options of antibiotics in pipeline, the effective clinician in today's hospital environment must utilize all available laboratory and clinical data in the selection of the optimal antibiotic therapy for the critically ill patient. Antibiotics must be utilized in a manner that ensures not only a maximally favorable outcome for the individual patient but, also, the minimization of
more » ... the minimization of subsequent antimicrobial resistance. All antibiotic use has potential public health consequences and, in this way, differs from the use of all other classes of pharmaceutical agents. Present review focuses on the application of pharmacokinetic/pharmacodynamic principles and their role in the combination of Cefoperazone-sulbactam.