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Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5
Membrane-bound sialidases in the mouse thymus are unique and mysterious because their activity at pH 6.5 is equal to or higher than that in the acidic region. The pH curve like this has never been reported in membrane-bound form. To clarify this enzyme, we studied the sialidase activities of crude membrane fractions from immature-T, mature-T and non-T cells from C57BL/6 mice and from SM/J mice, a strain with a defect in NEU1 activity. Non-T cells from C57BL/6 mice had high activity at pH 6.5,doi:10.1093/glycob/cwy009 pmid:29897583 fatcat:c4l3vxitprhorp3cw2bfpkmyf4