A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
A genome-wide genetic screen for host factors required for hepatitis C virus propagation
2009
Proceedings of the National Academy of Sciences of the United States of America
Hepatitis C virus (HCV) infection is a major cause of end-stage liver disease and a leading indication for liver transplantation. Current therapy fails in many instances and is associated with significant side effects. HCV encodes only a few proteins and depends heavily on host factors for propagation. Each of these host dependencies is a potential therapeutic target. To find host factors required by HCV, we completed a genome-wide small interfering RNA (siRNA) screen using an infectious HCV
doi:10.1073/pnas.0907439106
pmid:19717417
pmcid:PMC2752535
fatcat:ekxc47epcvdl3oc2bwdhhw5qnq