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Gas biology: Tiny molecules controlling metabolic systems
Respiratory Physiology & Neurobiology
It has been recognized that gaseous molecules and their signaling cascades play a vital role in alterations of metabolic systems in physiologic and pathologic conditions. Contrary to this awareness, detailed mechanisms whereby gases exert their actions, in particular in vivo, have been unclear because of several reasons. Gaseous signaling involves diverse reactions with metal centers of metalloproteins and thiol modification of cysteine residues of proteins. Both the multiplicity of gas targetsdoi:10.1016/j.resp.2012.03.016 pmid:22516267 fatcat:4yo56pqgfvf2hofojmwkm3vxcq