The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses [entry]

Gil Stelzer, Naomi Rosen, Inbar Plaschkes, Shahar Zimmerman, Michal Twik, Simon Fishilevich, Tsippi Iny Stein, Ron Nudel, Iris Lieder, Yaron Mazor, Sergey Kaplan, Dvir Dahary (+6 others)
2016 Current Protocols in Bioinformatics   unpublished
GeneCards, the human gene compendium, enables researchers to effectively navigate and inter-relate the wide universe of human genes, diseases, variants, proteins, cells, and biological pathways. Our recently launched Version 4 has a revamped infrastructure facilitating faster data updates, better-targeted data queries, and friendlier user experience. It also provides a stronger foundation for the GeneCards suite of companion databases and analysis tools. Improved data unification includes
more » ... tion includes gene-disease links via MalaCards and merged biological pathways via PathCards, as well as drug information and proteome expression. VarElect, another suite member, is a phenotype prioritizer for next-generation sequencing, leveraging the GeneCards and MalaCards knowledgebase. It automatically infers direct and indirect scored associations between hundreds or even thousands of variant-containing genes and disease phenotype terms. Var-Elect's capabilities, either independently or within TGex, our comprehensive variant analysis pipeline, help prepare for the challenge of clinical projects that involve thousands of exome/genome NGS analyses. C 2016 by John Wiley & Sons, Inc. Keywords: biological database r bioinformatics r diseases r GeneCards r gene prioritization r human genes r integrated information retrieval r next generation sequencing r VarElect
doi:10.1002/cpbi.5 pmid:27322403 fatcat:lksjgzmwx5a4fasqtoeawwglpe