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Expression of interferon regulatory factor 5 is regulated by the Sp1 transcription factor
2016
Molecular Medicine Reports
The transcription factor, interferon regulatory factor 5 (IRF5), is important in the induction of type I interferon, proinflammatory cytokines and chemokines, and is involved in autoimmune diseases and tumourigenesis. However, the mechanisms underlying the transcriptional regulation of wild-type IRF5 remain to be fully elucidated. The present study was primarily designed to clarify whether specificity protein 1 (Sp1) was involved in the regulation of IRF5. Initially, the IRF5 promoter region
doi:10.3892/mmr.2016.5565
pmid:27484157
fatcat:lmbpmaotxjf55d642hsksm2dfi