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Long-Term Animal Model of Venovenous Extracorporeal Membrane Oxygenation with Atrial Septal Defect as a Bridge to Lung Transplantation
2013
ASAIO journal (1992)
This study evaluated the effectiveness of an atrial septal defect (ASD) with veno-venous extracorporeal membrane oxygenation (vvECMO) as a bridge to transplantation. Sheep (56 ± 3 kg; n = 7) underwent a right sided thoracotomy to create the ASD (diameter = 1 cm) and place instrumentation and a pulmonary artery (PA) occluder. After recovery, animals were placed on ECMO, and the PA was constricted to generate a two-fold rise in right ventricular systolic pressure. Sheep were then maintained for
doi:10.1097/mat.0b013e3182a91ddb
pmid:24172261
pmcid:PMC3836596
fatcat:7ko4qvywtnar5mmg6b236iqjxq