High-density mapping of brain slices using a large multi-functional high-density CMOS microelectrode array system

Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Marie Obien, Jan Muller, Yihui Chen, Andreas Hierlemann
2017 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)  
We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices in-vitro with multiple readout modalities. The 4.48×2.43 mm 2 array consists of 59,760 micro-electrodes at 13.5 µm pitch (5487 electrodes/mm 2 ). The overall system features 2048 action-potential, 32 local-field-potential and 32 current recording channels, 32 impedance-measurement and 28 neurotransmitter-detection channels and 16 voltage/ current stimulation channels. The
more » ... ystem enables real-time and label-free monitoring of position, size, morphology and electrical activity of brain slices.
doi:10.1109/transducers.2017.7994006 pmid:28868212 pmcid:PMC5580803 fatcat:45onrfmsk5bppab7xuhjbmjoyi