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VEGFA′s distal enhancer regulates its alternative splicing in CML
[article]
2021
bioRxiv
pre-print
Enhancer demethylation in leukemia and lymphoma was shown to lead to overexpression of genes which promote cancer characteristics. The vascular endothelial growth factor A (VEGFA) enhancer, located 157 Kb downstream of its promoter, is demethylated in chronic myeloid leukemia (CML). VEGFA has several alternative splicing isoforms with different roles in vascularization and cancer progression. Since transcription and splicing are coupled in space and time, we hypothesized that the VEGFA enhancer
doi:10.1101/2021.01.09.426072
fatcat:nzissml4l5c2vfgu74h3bezb6y