Prediction of Mefenamic Acid Solubility and Molecular Interaction Energies in Different Classes of Organic Solvents and Water [component]

unpublished
Determination of solubility data either through experimental-or model-based approaches becomes a necessity in the crystallization of pharmaceutical compounds. The current work predicts the mefenamic acid solubility and molecular interaction energy, namely electrostatic (H-MF), hydrogen bonding (H-HB), and van der Waals (H-vdW), in different solvents at temperatures from 298 to 323 K using the conductor-like screening model for real solvents (COSMO-RS). Engineering uncontrolled terms
more » ... d terms Conductor-like screening model for real solvents Gibbs free energy changes Intermolecular interaction energies Model based approach Molecular interaction energy ▻ Authors ▻ Keywords ×
doi:10.1021/acs.iecr.8b02722.s001 fatcat:wqb6cehq5berlfcgbpsczqenpm