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60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease
Journal of Molecular Endocrinology
The cloning of the bovine proopiomelanocortin (POMC) cDNA in 1978 by Nakanishi and colleagues was the result of a remarkable series of exacting and ingenious experiments. With this work, they instantly confirmed the single precursor hypothesis for adrenocorticotrophic hormone-β-lipotropin, as it was then known, and in so doing revealed the existence of additional, largely unpredicted, N-terminal peptides that together formed the POMC precursor peptide. This work paved the way for a host ofdoi:10.1530/jme-15-0268 pmid:26643913 fatcat:5wx2wijo3zfxzk6sjvgwcgp6ju