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Mitochondrial genome recovery by ATFS-1 is essential for development following starvation
Nutrient availability regulates the C. elegans life cycle as well as mitochondrial physiology. Food deprivation significantly reduces mitochondrial genome (mtDNA) number and leads to aging-related phenotypes. Here, we demonstrate that the bZIP protein ATFS-1, a mediator of the mitochondrial unfolded protein response (UPRmt), is required to promote growth and establish a functional germline following prolonged starvation. Surprisingly, we found that the recovery of mtDNA copy number anddoi:10.1101/2022.05.19.492689 fatcat:4ydlmpxstrcpvpgngw6hfacx6y