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Perivascular adipose tissue (PVAT) has emerged in the past decades as an integral part of the vasculature (tunica adiposa), contributing by the release of adipokines, to important physiological process such as vascular tone regulation. The metabolic syndrome is associated with an increase deposition of PVAT and the development of atherosclerosis. Whereas healthy PVAT protect the vasculature from inflammation, lipid accumulation and hypothermia, the dysfunctional PVAT observed in the metabolicfatcat:dmgs42ikgfbwhe3gx5kwrref7q